David Goffin (BEL x21) bt Christian Garín (CHI) 6-0, 6-2, 6-2

Ryan Harrison (USA) bt Jiri Vesely (CZE) 6-0, 7-5, 6-3

Daniil Medvedev (RUS x15) bt Lloyd Harris (RSA) 6-1, 6-2, 6-1

Fabio Fognini (ITA x12) bt Jaume Munar (ESP) 7-6 (7/3), 7-6 (9/7), 3-1 retired

Leonardo Mayer (ARG) bt Nicolas Jarry (CHI) 7-6 (7/4), 7-6 (7/3), 4-6, 6-3

Ilya Ivashka (BLR) bt Malek Jaziri (TUN) 4-6, 7-6 (8/6), 6-1, 4-0 retired

Ivo Karlovic (CRO) bt Hubert Hurkacz (POL) 6-7 (5/7), 7-6 (7/5), 7-6 (7/3), 7-6 (7/5)

Kei Nishikori (JPN x8) bt Kamil Majchrzak (POL) 3-6, 6-7 (6/8), 6-0, 6-2, 3-0 retired

Alexander Zverev (GER x4) bt Aljaz Bedene (SLO) 6-4, 6-1, 6-4

Alex Bolt (AUS) bt Jack Sock (USA) 4-6, 6-3, 6-2, 6-2

Gilles Simon (FRA x29) bt Bjorn Fratangelo (USA) 7-6 (7/2), 6-4, 6-2

Pierre-Hugues Herbert (FRA) bt Sam Querrey (USA) 5-7, 7-6 (8/6), 6-3, 6-1

Borna Coric (CRO x11) bt Steve Darcis (BEL) 6-1, 6-4, 6-4

Marton Fucsovics (HUN) bt Albert Ramos (ESP) 6-3, 6-4, 6-7 (5/7), 6-3

Pablo Carreno-Busta (ESP x23) bt Luca Vanni (ITA) 6-7 (5/7), 2-6, 6-3, 7-5, 6-4

Joao Sousa (POR) bt Guido Pella (ARG) 7-6 (7/2), 4-6, 7-6 (7/5), 4-6, 6-2

Ivo Karlovic (CRO) bt Hubert Hurkacz (POL) 6-7 (5/7), 7-6 (7/5), 7-6 (7/3), 7-6 (7/5)

Chung Hyeon (KOR x24) bt Bradley Klahn (USA) 6-7 (5/7), 6-7 (5/7), 6-3, 6-2, 6-4

Evgeny Donskoy (RUS) bt Laslo Djere (SRB) 6-7 (5/7), 6-4, 6-1, 7-6 (7/5)